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KMID : 0350519950480010169
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.169 ~ p.176
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The Effect of Magnesium Pretreatment on Serum Potassium Concentration and Hemodynamic State in Rabbits during Continuous Regular Insulin(RI) Infusion
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Abstract
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We evaluated the effect of magnesium sulfate treatment on hemodynamics and serum potassium concentration, induced by continuous infusion of regular insulin solution in rabbits anesthetized with urethane. Twenty-four rabbits were divided into four
groups
for the experiment. GroupⅠwas given intravenouse injection of 5 ml of normal saline and continuous dripping of 7.5 U of RI. GroupⅡwas pretreated with 30 mg/kg of magnesium sulfate. Followed by continuous dripping of 7.5 U of RI. GroupⅢwas
given
5 ml
of normal saline and 15 U of RI. And GroupⅣwas administered 15 U of RI after 30 mg/kg of magnesium sulfate pretreatment.
Venouse blood sampling was done before ppreatment, and after 5, 30, 60 and 120 minutes respectively. Heart rate and arterial blood pressure were taken at the same intervals.
@ES The results were as follows :
@EN 1) There was no significant change in serum potassium concentration in groups injected with 7.5 units of RI respectively(groupsⅠandⅡ), regardless of magnesium pretreatment. But in groups in jected with 15 units of RI, the group that was not
pretreated with magnesium(Groups Ⅲ) showed a decrease in serum potassium concentration from 3.39±3.39±0.57 Eq/L to 2.29Ⅳ0.71 mEq/L, while the concentration in the pretreated grloup9GroupⅣ) decreased more significantly from 3.35±0.50 mEq/L
to
1.81±0.42 mEq/L.
2) Pulse rate did not change significantly in groups that received continuous infusion of 7.5 units of RI(groupsⅠandⅡ) regardless of magnesium preatment, but increased significantly in groups injected with 15 units of RI9groupsⅢandⅣ),
pretreated or
not. The pretreated group9groupⅣ) had a more significant rise in pulse rate compared with the group that was not pretreated(groupⅢ).
3) In all groups pretreated with magnesium(groupsⅡandⅣ) and not pretreated(grpupsⅠandⅢ), there was no significant change in systolic and diastolic blood pressures. Nor was arrhythmia detected.
The above results indicate that while magnesium sulfate pretreatment at 30 mg/kg with insulin infusion affects serum potassium concentration, has an antiarrhythmic effect, and may induce tachycardia, it does not have any significant effect on
blood
pressure.
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